Associations Between Serum Uric Acid Concentrations and Cardiometabolic Risk and Renal Injury in Obese and Overweight Children
| dc.contributor.author | Deniz KIZILAY | |
| dc.contributor.author | Semra ŞEN | |
| dc.contributor.author | Betül ERSOY | |
| dc.date.accessioned | 2024-07-24T09:09:55Z | |
| dc.date.available | 2024-07-24T09:09:55Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Objective: The aim of this study was to assess the association between serum uric acid concentration (SUAC) and the parameters of themetabolic syndrome (MetS) and insulin resistance (IR). The secondary aim was to evaluate whether hyperuricemia is associated withrenal injury and cardiovascular risk in obese (OB) and overweight (OW) children.Methods: The subjects of this study consisted of OB/OW children and adolescents (ages: 8-18 years). Sex and age specific serum uricacid (SUA) olarak değiştirilecek percentiles were used and a SUA >75th percentile was accepted as hyperuricemia. Anthropometricdata, blood pressure (BP) measurements and biochemical parameters, including fasting blood glucose, insulin, total cholesterol, highdensity lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol, triglycerides (TG), aspartate aminotransferase, alanineaminotransferase, homeostatic model assessments of IR (HOMA-IR) and SUAC were recorded. Oral glucose tolerance tests (OGTT) wereperformed in all patients. MetS was defined according to the International Diabetes Federation criteria. Total cholesterol/HDL-c ratio >4and TG/HDL-c ratio >2.2 were used as the atherogenic index (AI) indicating cardiovascular risk. Urinary albumin excretion in a 24-hourand also in a first-morning urine sample were measured. Renal injury was assessed by microalbuminuria according to the NationalKidney Foundation criteria.Results: There were 128 participants; 52 (40%) had elevated (SUA >75th percentile) and 76 had (60%) normal SUAC. The mean±SDage was 13.1±2.6 years and 87 (67.4%) were female. The mean±SD weight was 73±18.97 kg and mean±SD height was 155.4±12.11cm. There was no statistical difference between the groups with and without hyperuricemia in terms of age, sex, puberty stage anddegree of obesity. Increased SUAC were significantly associated with higher waist-to-hip ratio (WHR), fasting insulin levels and insulinat 30 and 60 minutes during OGTT, HOMA-IR, lower HDL-c and presence of hypertriglyceridemia as well as with decreased HDL-c,increased AI, presence of IR and MetS. BP and microalbuminuria were not associated with SUAC. SUAC showed significant positivecorrelations with waist circumference, WHR, post-challenge glucose level at 60 minutes, with fasting insulin, post-challenge insulin levelsat 30, 60, 90 and 120 minutes and also with HOMA-IR, total cholesterol/HDL-c ratio, TG/HDL-c ratio and a number of other criteriarelated to MetS. Also, an inverse correlation with HDL-c was noted.Conclusion: In OB/OW children frequency of MetS, IR and dislipidemia increases with increased SUAC, a finding independent of age,puberty, gender and body mass index. Patients meeting all of the MetS criteria had the highest SUAC. These results demonstrate thatthe association between UA and metabolic and cardiovascular risk factors can be detected early in childhood. Thus, we recommendmonitoring SUAC in OB children and we believe that prevention of SUAC elevation in early life has a potential protective effect onmetabolic impairment and subsequent comorbidities. | |
| dc.identifier.DOI-ID | 10.4274/jcrpe.galenos.2018.2019.0241 | |
| dc.identifier.issn | 1308-5727 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/22492 | |
| dc.language.iso | eng | |
| dc.subject | [Fen > Tıp > Endokrinoloji ve Metabolizma, Fen > Tıp > Pediatri] | |
| dc.title | Associations Between Serum Uric Acid Concentrations and Cardiometabolic Risk and Renal Injury in Obese and Overweight Children | |
| dc.type | Araştırma Makalesi |