Are human adenovirus-5 and 36 associated with obesity in children?
| dc.contributor.author | Cakmakliogullari E.K. | |
| dc.contributor.author | Sanlidag T. | |
| dc.contributor.author | Ersoy B. | |
| dc.contributor.author | Akcali S. | |
| dc.contributor.author | Var A. | |
| dc.contributor.author | Cicek C. | |
| dc.date.accessioned | 2025-04-10T11:13:23Z | |
| dc.date.available | 2025-04-10T11:13:23Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Objectives: The aims of this study were to determine the association between adenovirus-5- and adenovirus-36-specific antibodies and obesity in children and to investigate their relationship with serum lipid and leptin levels. Methods: A cross-sectional study was performed on a total of 120 children who were divided into subgroups according to body mass index percentile as obese (Q95th percentile) or nonobese (G95th percentile). The presence of adenovirus-36 and adenovirus-5-neutralizing antibodies was investigated by using the serum neutralization assay. Serum leptin levels were determined by microenzyme immonoassay; highdensity lipoprotein, low-density lipoprotein, triglyceride, and cholesterol levels were measured by chemiluminescence method. Results: The presence of adenovirus-5-specific antibodies was 28.3% and 6.6% in the obese children and in non-obese children, respectively (P = 0.02). The frequency of adenovirus-36-specific antibodies was significantly greater (P = 0.018) in the obese children (26.6%) than in the non-obese children (10.0%). Serum leptin level of the obese group were significantly higher than that of the non-obese group (P = 0.000). Conclusions: Our data support the association between obesity and the presence of specific antibodies to adenovirus-36 and adenovirus-5 in children. Our research has the feature of being the first national study to indicate the relationship between adenovirus-36 and human obesity as well as the first international study to indicate the relationship between adenovirus-5 and human obesity. Copyright © 2014 by The American Federation for Medical Research. | |
| dc.identifier.DOI-ID | 10.2310/JIM.0000000000000084 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/49868 | |
| dc.publisher | BMJ Publishing Group | |
| dc.title | Are human adenovirus-5 and 36 associated with obesity in children? | |
| dc.type | Article |