The effects of sunitinib on endometriosis

Simple item page
dc.contributor.authorPala, HG
dc.contributor.authorErbas, O
dc.contributor.authorPala, EE
dc.contributor.authorUlkumen, BA
dc.contributor.authorAkman, L
dc.contributor.authorAkman, T
dc.contributor.authorOltulu, F
dc.contributor.authorYavasoglu, A
dc.date.accessioned2024-07-18T12:06:11Z
dc.date.available2024-07-18T12:06:11Z
dc.description.abstractThe aim of the present study was to evaluate the effect of sunitinib on endometriotic implants and adhesions in a rat endometriosis model. An experimental endometriosis model was created in 21 rats. These rats were randomly divided into three groups: Group 1 (control group, 7 rats) was given no medication; Group 2 (sunitinib group, 7 rats) was given 3 mg/kg per day of oral sunitinib; and Group 3 (danazol group, 7 rats) was given 7.2 mg/kg per day of oral danazol. The volume of endometriotic implants was calculated. The extent and severity of adhesions were evaluated. The groups were compared by the Student's t-test, analysis of variance (ANOVA) and the Mann-Whitney U test. There was no statistically significant difference in the mean volume of endometriotic implants before medication between three groups. The volume of implants and extent, severity, total score of adhesions were significantly decreased after medication in Group 2 and Group 3. We noted that the volume of the endometriotic implants and adhesion formation were decreased both after sunitinib and danazol treatment. As a result, sunitinib seems to be effective for endometriotic peritoneal lesions. The effects of sunitinib in rat models give hope for improving the treatment of human endometriosis and prevention of pain symptoms.
dc.identifier.issn0144-3615
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10242
dc.language.isoEnglish
dc.publisherINFORMA HEALTHCARE
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectNF-KAPPA-B
dc.subjectLONG PENTRAXIN PTX3
dc.subjectCHORIOALLANTOIC MEMBRANE
dc.subjectINNATE IMMUNITY
dc.subjectMODEL
dc.subjectINFLAMMATION
dc.subjectANGIOGENESIS
dc.subjectRECOGNITION
dc.subjectINHIBITORS
dc.titleThe effects of sunitinib on endometriosis
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu