Maternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokines

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dc.contributor.authorYilmaz O.
dc.contributor.authorYasar A.
dc.contributor.authorCaliskan Polat A.
dc.contributor.authorAy P.
dc.contributor.authorAlkin T.
dc.contributor.authorTaneli F.
dc.contributor.authorOdabasi Cingoz F.
dc.contributor.authorHasdemir P.S.
dc.contributor.authorSimsek Y.
dc.contributor.authorYuksel H.
dc.date.accessioned2024-07-22T08:06:02Z
dc.date.available2024-07-22T08:06:02Z
dc.date.issued2021
dc.description.abstractRationale: Maternal psychosocial stress might be associated with development of allergic diseases in the offspring. Objectives: To evaluate the association of maternal depression and anxiety with ever wheezing and recurrent wheezing among infants and to assess the role of maternal hypothalamo-pituatary-adrenal axis changes and fetal immune response in this association. Methods: This study encompasses two designs; cohort design was developed to evaluate the association of prenatal depression with development of wheezing in infants while nested case–control design was used to assess the role of maternal cortisol and tetranectin and cord blood interleukin 13 and interferon γ. Results: We enrolled 697 pregnant women. Elementary school graduate mother (odds ratio [OR] = 1.5, p =.06), maternal smoking during pregnancy (OR = 3.4, p =.001), familial history of asthma (OR = 2.7, p <.001) increased the risk of ever wheezing. Elementary school graduate mother (OR = 2.6, p =.002), maternal smoking during pregnancy (OR = 4.8, p <.001) and familial history of asthma (OR = 1.7, p =.01) increased the risk of recurrent wheezing. Maternal previous psychiatric disease, or Edinburgh Postnatal Depression Scale or Spielberger State-Trait Anxiety Inventory scores were not associated with wheezing. Maternal tetranectin levels were significantly higher among never wheezers compared to the ever wheezers (264.3 ± 274.8 vs. 201.6 ± 299.7, p =.04). Conclusions: In conclusion, the major risk factors for ever wheezing and recurrent wheezing were maternal smoking, level of education and family history of asthma. However, maternal depression and anxiety were not determined as risk factors for wheezing. Maternal tetranectin carries potential as a biomarker for wheezing in the infant. © 2021 Wiley Periodicals LLC
dc.identifier.DOI-ID10.1002/ppul.25302
dc.identifier.issn87556863
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13358
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectCytokines
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectInfant
dc.subjectMothers
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectRespiratory Sounds
dc.subjectbiological marker
dc.subjectcytokine
dc.subjectgamma interferon
dc.subjecthormone
dc.subjecthydrocortisone
dc.subjectinterleukin 13
dc.subjecttetranectin
dc.subjectcytokine
dc.subjecthydrocortisone
dc.subjectadult
dc.subjectanxiety
dc.subjectArticle
dc.subjectcase control study
dc.subjectclinical assessment
dc.subjectclinical evaluation
dc.subjectclinical feature
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease course
dc.subjectEdinburgh Postnatal Depression Scale
dc.subjecteducational status
dc.subjectfemale
dc.subjecthealth hazard
dc.subjecthormone action
dc.subjecthuman
dc.subjecthypothalamus hypophysis adrenal system
dc.subjectimmune response
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmaternal smoking
dc.subjectmental health
dc.subjectnewborn
dc.subjectpostnatal depression
dc.subjectrecurrent disease
dc.subjectrisk factor
dc.subjectState Trait Anxiety Inventory
dc.subjectumbilical cord blood
dc.subjectwheezing
dc.subjectabnormal respiratory sound
dc.subjectfetus blood
dc.subjectmother
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.titleMaternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokines
dc.typeArticle

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