Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses
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Date
2010
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Abstract
The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-β-l-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-α-d-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans. © 2010 Elsevier Ltd. All rights reserved.
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Keywords
Amino Sugars , Anti-Infective Agents , Bacteria , Chloralose , Fungi , Microbial Sensitivity Tests , Stereoisomerism , Candida albicans , Negibacteria , Posibacteria , Amines , Bacteria , Sugar (sucrose) , 1,2 o trichloroethylidene beta levo arabinofuranose , 3,5 di o acetyl trichloroethylidene beta levo arabinofuranose , 5 acetamido 5 deoxy 3 o acetyl 1,2 o trichloroethylidene beta levo arabinofuranose , 5 amino 5 deoxy 1,2 o trichloroethylidene beta levo arabinofuranose , 5 azido 5 deoxy 1,2 o trichloroethylidene beta levo arabinofuranose , 5 o tosyl 1,2 o trichloroethylidene beta levo arabinofuranose , 6 acetamido 6 deoxy 3,5 di o acetyl 1,2 o trichloroethylidene alpha dextro glucofuranose , 6 amino 6 deoxy 1,2 o trichloroethylidene alpha dextro glucofuranose , 6 azido 6 deoxy 1,2 o trichloroethylidene alpha dextro glucofuranose , 6 o tosyl 1,2 o trichloroethylidene alpha dextro glucofuranose , aminosugar , antibiotic agent , carbohydrate derivative , chloralose , chloramphenicol , nalidixic acid , nystatin , unclassified drug , aminosugar , antiinfective agent , Amino sugar , Anti-microbial activity , Candida albicans , Gram-negative bacteria , Inhibition zones , antibacterial activity , article , Bacillus cereus , Bacillus subtilis , Candida albicans , carbohydrate synthesis , competitive inhibition , controlled study , drug potency , drug structure , drug synthesis , Enterobacter aerogenes , Enterobacter cloacae , Enterococcus faecalis , Escherichia coli , minimum inhibitory concentration , nonhuman , priority journal , Proteus vulgaris , Salmonella typhimurium , Staphylococcus aureus , analogs and derivatives , Bacteria , chemistry , drug effects , fungus , microbial sensitivity test , stereoisomerism , synthesis , Complexation