Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3
| dc.contributor.author | Ersoy B. | |
| dc.contributor.author | Ozbilgin K. | |
| dc.contributor.author | Kasirga E. | |
| dc.contributor.author | Inan S. | |
| dc.contributor.author | Coskun S. | |
| dc.contributor.author | Tuglu I. | |
| dc.date.accessioned | 2025-04-10T11:16:00Z | |
| dc.date.available | 2025-04-10T11:16:00Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | AIM: To evaluate the effects of growth hormone (GH) on the histology of small intestines which might be related to the role of insulin like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP-3) and its receptors. METHODS: Twelve week-old adult male Wistar albino rats were divided into two groups. The study group ( n = 10), received recombinant human growth hormone (rGH) at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group ( n = 10) received physiologic serum. Paraffin sections of jejunum were stained with periodic acid shift (PAS) and hematoxylin and eosin (HE) for light microscopy. They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities. Staining intensity was graded semi-quantitatively using the HSCORE. RESULTS: Goblet cells and the cells in crypt epithelia were significantly increased in the study group compared to that of the control group. We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application. IGF-I receptor immunoreactivities of crypt, villous columnar cells, enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION: These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. © 2009 The WJG Press and Baishideng. All rights reserved. | |
| dc.identifier.DOI-ID | 10.3748/wjg.15.5418 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51460 | |
| dc.publisher | Baishideng Publishing Group Co | |
| dc.title | Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3 | |
| dc.type | Article |