The role of stem/progenitor cells and wnt/β-catenin signaling pathway in the patients with prostate cancer
| dc.contributor.author | Vatansever H.S. | |
| dc.contributor.author | Gumus B. | |
| dc.contributor.author | Aydogdu O. | |
| dc.contributor.author | Sivrikoz O.N. | |
| dc.contributor.author | Türkôz-Uluer E. | |
| dc.contributor.author | Kivanç M. | |
| dc.contributor.author | Ateşçi Y.Z. | |
| dc.contributor.author | Bugdayci H. | |
| dc.date.accessioned | 2025-04-10T11:11:17Z | |
| dc.date.available | 2025-04-10T11:11:17Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Aim: The aim of this paper was to investigate the possible effect of cancer stem cells (CSCs) and relationship with Wnt/β-catenin signaling pathway progressing of prostate cancer. Methods: Thirty men with a pathological diagnosis of benign prostate hyperplasia (BPH) (group 1, N.=10), prostate cancer with a gleason score of ≤6 (group 2, N.=10), and prostate cancer with a gleason score of >6 (group 3, N.=10) were included in the study. The patients' groups were compared in terms of immunoreactivity strength of prostatic stem/progenitor cell surface markers including CD133 and CD117. We also compared the immunoreactivity of Wnt7a, a part of Wnt signaling pathway which has a potential role in the progression of several cancers including prostate cancer. The immunoreactivity of Frizzled 6 (Fzd 6) which is the receptor of Wnt family was also evaluated in all groups. Results: Immunohistochemical analyses demonstrated that although CD 133 immunoreactivity was positive in all groups, immunoreactivity was significantly stronger in group 3 when compared to other groups. While CD117 immunoreactivity was negative in group 1 and 2, it was positive in group 3. Wnt7a immunoreactivity was weak in all groups and Fzd 6 immunoreactivity was stronger in group 1 and 3 when compared to group 2. Conclusion: Our findings demonstrated that CSCs and Wnt signaling pathway have a potential role in the development and progression of prostate cancer. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/49471 | |
| dc.publisher | Edizioni Minerva Medica | |
| dc.title | The role of stem/progenitor cells and wnt/β-catenin signaling pathway in the patients with prostate cancer | |
| dc.type | Article |