Scintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99mtechnetium-labelled human polyclonal immunoglobulin G
| dc.contributor.author | Cindaş A. | |
| dc.contributor.author | Gökçe-Kutsal Y. | |
| dc.contributor.author | Kirth P.O. | |
| dc.contributor.author | Caner B. | |
| dc.date.accessioned | 2025-04-10T11:18:10Z | |
| dc.date.available | 2025-04-10T11:18:10Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | The aim of this study was to investigate whether 99mtechnetium-labelled polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy reflects synovial inflammation in patients with rheumatoid arthritis (RA). We evaluated 29 patients with RA for this reason and found a highly significant correlation between total scintigraphic scores and total tenderness scores (r = 0.781, P < 0.001). A significant correlation was also found between 99mTc-IgG scintigraphic scores and tenderness in all joints other than the shoulders. The 99mTc-IgG scintigraphy had a sensitivity of 69% and specificity of 88% in cases with tenderness and 72% and 81%, respectively, in cases with swelling. Total scintigraphic scores were correlated with serum levels of C-reactive protein (r = 0.401, P < 0.05) but not with erythrocyte sedimentation rate (r = 0.149, P > 0.05). The correlation between disease activity scores and total scintigraphic scores was also found to be significant (r = 0.812, P < 0.001). We suggest that 99mTc-IgG scintigraphy is a reliable and objective method in detecting synovial activity and can be appropriate for observing disease prognosis in clinical trials with RA. | |
| dc.identifier.DOI-ID | 10.1007/s002960000081 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/53251 | |
| dc.title | Scintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99mtechnetium-labelled human polyclonal immunoglobulin G | |
| dc.type | Article |