A multimodal ophthalmic analysis in patients with systemic sclerosis using ocular response analyzer, corneal topography and specular microscopy
No Thumbnail Available
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Purpose: To conduct a multimodal ophthalmic evaluation of systemic sclerosis (SSc) in patients using ocular response analyzer (ORA), Pentacam, and specular microscopy (SM). Methods: Thirty-one SSc patients and a group of age- and sex-matched controls were enrolled in this cross-sectional study. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with ORA. Anterior chamber depth (ACD), central corneal thickness (CCT), and corneal volume (CV) measurements were obtained using Pentacam. Corneal endothelial cell density (ECD) and CCT were evaluated by SM. Results: SSc patients had significantly lower CH, ACD, and ECD values compared to the control group (p = 0.018; < 0.001; < 0.001, respectively). There was no significant difference regarding CRF, IOP, CV, or CCT measurements acquired by Pentacam and SM. Regarding CCT, SM and Pentacam showed relatively better agreement in SSc patients. Conclusions: Multimodal imaging can provide more comprehensive and useful information regarding the ocular involvement of systemic diseases. The multimodal evaluation in our study demonstrated that the pathologic effects of SSc may manifest as reductions in ACD, corneal elasticity, and ECD before there are any detectable changes in corneal thickness or IOP. © 2019, Springer Nature B.V.
Description
Keywords
Adult , Aged , Cornea , Corneal Diseases , Corneal Topography , Cross-Sectional Studies , Elasticity , Female , Follow-Up Studies , Forecasting , Humans , Intraocular Pressure , Male , Middle Aged , Multimodal Imaging , Scleroderma, Systemic , Tonometry, Ocular , adult , aged , anterior eye chamber depth , Article , cell density , central corneal thickness , clinical article , controlled study , cornea endothelium , corneal compensated intraocular pressure , corneal hysteresis , corneal resistance factor , corneal volume , cross-sectional study , endothelium cell , female , human , intraocular pressure , keratometry , male , observational study , specular microscopy , systemic sclerosis , visual system examination , visual system parameters , complication , cornea , cornea disease , elasticity , follow up , forecasting , keratometry , middle aged , multimodal imaging , oculoplethysmography , pathology , pathophysiology , procedures , systemic sclerosis