A multimodal ophthalmic analysis in patients with systemic sclerosis using ocular response analyzer, corneal topography and specular microscopy

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dc.contributor.authorMayali H.
dc.contributor.authorAltinisik M.
dc.contributor.authorSencan S.
dc.contributor.authorPirildar T.
dc.contributor.authorKurt E.
dc.date.accessioned2024-07-22T08:07:51Z
dc.date.available2024-07-22T08:07:51Z
dc.date.issued2020
dc.description.abstractPurpose: To conduct a multimodal ophthalmic evaluation of systemic sclerosis (SSc) in patients using ocular response analyzer (ORA), Pentacam, and specular microscopy (SM). Methods: Thirty-one SSc patients and a group of age- and sex-matched controls were enrolled in this cross-sectional study. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with ORA. Anterior chamber depth (ACD), central corneal thickness (CCT), and corneal volume (CV) measurements were obtained using Pentacam. Corneal endothelial cell density (ECD) and CCT were evaluated by SM. Results: SSc patients had significantly lower CH, ACD, and ECD values compared to the control group (p = 0.018; < 0.001; < 0.001, respectively). There was no significant difference regarding CRF, IOP, CV, or CCT measurements acquired by Pentacam and SM. Regarding CCT, SM and Pentacam showed relatively better agreement in SSc patients. Conclusions: Multimodal imaging can provide more comprehensive and useful information regarding the ocular involvement of systemic diseases. The multimodal evaluation in our study demonstrated that the pathologic effects of SSc may manifest as reductions in ACD, corneal elasticity, and ECD before there are any detectable changes in corneal thickness or IOP. © 2019, Springer Nature B.V.
dc.identifier.DOI-ID10.1007/s10792-019-01173-x
dc.identifier.issn01655701
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14138
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectAdult
dc.subjectAged
dc.subjectCornea
dc.subjectCorneal Diseases
dc.subjectCorneal Topography
dc.subjectCross-Sectional Studies
dc.subjectElasticity
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectForecasting
dc.subjectHumans
dc.subjectIntraocular Pressure
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultimodal Imaging
dc.subjectScleroderma, Systemic
dc.subjectTonometry, Ocular
dc.subjectadult
dc.subjectaged
dc.subjectanterior eye chamber depth
dc.subjectArticle
dc.subjectcell density
dc.subjectcentral corneal thickness
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcornea endothelium
dc.subjectcorneal compensated intraocular pressure
dc.subjectcorneal hysteresis
dc.subjectcorneal resistance factor
dc.subjectcorneal volume
dc.subjectcross-sectional study
dc.subjectendothelium cell
dc.subjectfemale
dc.subjecthuman
dc.subjectintraocular pressure
dc.subjectkeratometry
dc.subjectmale
dc.subjectobservational study
dc.subjectspecular microscopy
dc.subjectsystemic sclerosis
dc.subjectvisual system examination
dc.subjectvisual system parameters
dc.subjectcomplication
dc.subjectcornea
dc.subjectcornea disease
dc.subjectelasticity
dc.subjectfollow up
dc.subjectforecasting
dc.subjectkeratometry
dc.subjectmiddle aged
dc.subjectmultimodal imaging
dc.subjectoculoplethysmography
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectprocedures
dc.subjectsystemic sclerosis
dc.titleA multimodal ophthalmic analysis in patients with systemic sclerosis using ocular response analyzer, corneal topography and specular microscopy
dc.typeArticle

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