A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis
| dc.contributor.author | Kurt Ö. | |
| dc.contributor.author | Girginkardeşler N. | |
| dc.contributor.author | Balcioǧlu I.C. | |
| dc.contributor.author | Q̈zbilgin A. | |
| dc.contributor.author | Ok Ü.Z. | |
| dc.date.accessioned | 2025-04-10T11:16:36Z | |
| dc.date.available | 2025-04-10T11:16:36Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Recent reports of the pathogenic potential of Dientamoeba fragilis have underlined the need for an effective treatment against this colon-dwelling protozoan. Metronidazole is a well-known and commonly used anti-protozoal agent, but another 5-nitroimidazole derivative, ornidazole, may be preferable, where available, because of its longer half-life and fewer side-effects. This study compared the efficacies of metronidazole and ornidazole in a group of 112 patients with dientamoebiasis. Patients were randomised into two treatment groups: group.1 (n = 56) received metronidazole for 5 days, 20 mg/kg/day for children and 1.5 g/day for adults, in three oral doses, while group 2 (n = 56) received a single oral dose of ornidazole, 30 mg/kg for children and 2g for adults. Stool samples were examined on the seventh and 14th days after treatment, and clinical symptoms were recorded to evaluate the efficacy of treatment. A statistically significant difference was recorded between the efficacies of ornidazole and metronidazole, both parasitologically (92.9% vs. 69.6%, p 0.001) and clinically (96.4% vs. 76.8%, p 0.001). Patients in the metronidazole group reported more side-effects than patients in the ornidazole group, none of whom required termination of treatment. These results suggest that single-dose ornidazole may be an important alternative agent for the treatment of dientamoebiasis. © 2008 European Society of Clinical Microbiology and Infectious Diseases. | |
| dc.identifier.DOI-ID | 10.1111/j.1469-0691.2008.02002.x | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51938 | |
| dc.publisher | Blackwell Publishing Ltd | |
| dc.title | A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis | |
| dc.type | Article |