LC-MS/MS profiles and interrelationships between the enzyme inhibition activity, total phenolic content and antioxidant potential of Micromeria nervosa extracts

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dc.contributor.authorSarikurkcu C.
dc.contributor.authorAndrade J.C.
dc.contributor.authorOzer M.S.
dc.contributor.authorde Lima Silva J.M.F.
dc.contributor.authorCeylan O.
dc.contributor.authorde Sousa E.O.
dc.contributor.authorCoutinho H.D.M.
dc.date.accessioned2024-07-22T08:07:08Z
dc.date.available2024-07-22T08:07:08Z
dc.date.issued2020
dc.description.abstractThe objective of this study was to quantify the phenolic compounds and to evaluate and compare the biological activities of the ethyl acetate (EtOAc), methanolic (MeOH) and aqueous extracts from the Micromeria nervosa aerial parts, based on their antioxidant activity and enzymatic inhibition. Total phenolic and flavonoid contents were calculated and individual compo3unds were detected using LC-ESI-MS/MS. The antioxidant activity was determined using six different assays while enzymatic activity was determined by α-amylase and tyrosinase enzyme inhibition. The main phenolic constituents detected in the extracts were rosmarinic acid. In the antioxidant assays the aqueous extract was shown to be more efficient than the others. The EtOAc and MeOH extracts presented higher inhibitory activity with respect to α-amylase and tyrosinase. Regardless of the solvent, the results suggest M. nervosa aerial extracts present a biological potential due to their antioxidant activity and enzymatic inhibition. © 2020 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.foodchem.2020.126930
dc.identifier.issn03088146
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13845
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectalpha-Amylases
dc.subjectAntioxidants
dc.subjectChromatography, High Pressure Liquid
dc.subjectCinnamates
dc.subjectDepsides
dc.subjectEnzyme Inhibitors
dc.subjectFlavonoids
dc.subjectLamiaceae
dc.subjectMonophenol Monooxygenase
dc.subjectPhenols
dc.subjectPlant Components, Aerial
dc.subjectPlant Extracts
dc.subjectTandem Mass Spectrometry
dc.subjectAmylases
dc.subjectAntennas
dc.subjectAntioxidants
dc.subjectEnzyme activity
dc.subjectPlants (botany)
dc.subjectacetic acid ethyl ester
dc.subjectamylase
dc.subjectantioxidant
dc.subjectmonophenol monooxygenase
dc.subjectNervosa micromeria extract
dc.subjectphenol derivative
dc.subjectplant extract
dc.subjectrosmarinic acid
dc.subjectunclassified drug
dc.subjectantioxidant
dc.subjectcinnamic acid derivative
dc.subjectdepside
dc.subjectenzyme inhibitor
dc.subjectflavonoid
dc.subjectphenol derivative
dc.subjectplant extract
dc.subjectAnti-oxidant activities
dc.subjectAntioxidant potential
dc.subjectBiological potential
dc.subjectEnzymatic activities
dc.subjectInhibition activity
dc.subjectInhibitory activity
dc.subjectPhenolic compounds
dc.subjectTotal phenolic content
dc.subjectaerial plant part
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectIC50
dc.subjectliquid chromatography-mass spectrometry
dc.subjectmedicinal plant
dc.subjectNervosa micromeria
dc.subjectchemistry
dc.subjecthigh performance liquid chromatography
dc.subjectLamiaceae
dc.subjectmetabolism
dc.subjecttandem mass spectrometry
dc.subjectEnzyme inhibition
dc.titleLC-MS/MS profiles and interrelationships between the enzyme inhibition activity, total phenolic content and antioxidant potential of Micromeria nervosa extracts
dc.typeArticle

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