Discriminant validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis: A cohort study

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dc.contributor.authorKilic E.
dc.contributor.authorKilic G.
dc.contributor.authorAkgul O.
dc.contributor.authorOzgocmen S.
dc.date.accessioned2024-07-22T08:13:08Z
dc.date.available2024-07-22T08:13:08Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to assess discriminant validity of Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) and to compare with The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) as clinical tools for the measurement of disease activity in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS). Also, the cut-off values for ASDAS-CRP in nr-axSpA and AS is revisited. Patients with axSpA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and were assessed for disease activity, quality of life and functional measures. The discriminatory ability of ASDAS-CRP and ASDAS-ESR was assessed using standardized mean differences and receiver operating characteristic (ROC) curves analysis. Optimal cut-off values for disease activity scores were calculated. Two hundred and eighty-seven patients with axSpA (nr-axSpA:132, AS:155) were included in this study. Two ASDAS versions and BASDAI had good correlations with patient’s and physician’s global assessment in both groups. Discriminatory ability of ASDAS-CRP, ASDAS-ESR and BASDAI were similar in patients with nr-axSpA and AS when the patients were assigned into low and high disease activity according to the ASAS partial remission, patient’s and physician’s global assessment scores (based on the comparison of ROC curves). ASDAS cut-off values are quite similar between groups indicating that ASDAS-CRP works similarly well in nr-axSpA and AS. The performance of ASDAS to discriminate low and high disease activity and cut-off values are quite similar in patients with AS and non-radiographic axial SpA. © 2014, Springer-Verlag Berlin Heidelberg.
dc.identifier.DOI-ID10.1007/s00296-014-3168-y
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16277
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectAdult
dc.subjectArea Under Curve
dc.subjectBiomarkers
dc.subjectBlood Sedimentation
dc.subjectC-Reactive Protein
dc.subjectDecision Support Techniques
dc.subjectDiagnosis, Differential
dc.subjectDiscriminant Analysis
dc.subjectFemale
dc.subjectHealth Status
dc.subjectHumans
dc.subjectInflammation Mediators
dc.subjectMale
dc.subjectPain Measurement
dc.subjectPredictive Value of Tests
dc.subjectQuality of Life
dc.subjectReproducibility of Results
dc.subjectROC Curve
dc.subjectSeverity of Illness Index
dc.subjectSpondylarthritis
dc.subjectSpondylitis, Ankylosing
dc.subjectSurveys and Questionnaires
dc.subjectC reactive protein
dc.subjectmethotrexate
dc.subjectnonsteroid antiinflammatory agent
dc.subjecttumor necrosis factor alpha inhibitor
dc.subjectautacoid
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectadult
dc.subjectankylosing spondylitis
dc.subjectAnkylosing Spondylitis Disease Activity Score
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectBath ankylosing spondylitis disease activity index
dc.subjectBath ankylosing spondylitis functional index
dc.subjectclinical feature
dc.subjectcohort analysis
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectdiscriminant validity
dc.subjectdisease activity score
dc.subjecterythrocyte sedimentation rate
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnon radiographic axial spondyloarthritis
dc.subjectnon radiographic axial spondyloarthritis
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectquality of life
dc.subjectreceiver operating characteristic
dc.subjectsensitivity and specificity
dc.subjectspondylarthritis
dc.subjectvisual analog scale
dc.subjectblood
dc.subjectcomparative study
dc.subjectdecision support system
dc.subjectdifferential diagnosis
dc.subjectdiscriminant analysis
dc.subjecterythrocyte sedimentation rate
dc.subjecthealth status
dc.subjectimmunology
dc.subjectpain measurement
dc.subjectpredictive value
dc.subjectquestionnaire
dc.subjectreproducibility
dc.subjectseverity of illness index
dc.subjectspondylarthritis
dc.subjectSpondylitis, Ankylosing
dc.subjectvalidation study
dc.titleDiscriminant validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis: A cohort study
dc.typeArticle

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