The expression of forkhead transcription factors in decidua and placenta in patients with missed abortion

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dc.contributor.authorOzbilgin K.
dc.contributor.authorKahraman B.
dc.contributor.authorTuran A.
dc.contributor.authorAtay C.
dc.contributor.authorVatansever S.
dc.contributor.authorInan S.
dc.contributor.authorÖzçakir T.
dc.date.accessioned2024-07-22T08:14:14Z
dc.date.available2024-07-22T08:14:14Z
dc.date.issued2015
dc.description.abstractBackground: Forkhead transcription factors 3a (FOX03a) has pleiotropic biological functions in the female reproductive tract. FOX03a has a function in decidualization, in placental development, and also in inhibition of apoptosis. This study aims to investigate a possible role of FOX03a in missed abortion. Materials and Methods: Decidual and placental tissue samples were obtained from the women with unwanted pregnancy as the control group and with missed abortion as the patient group. Immunohistochemistry technique was utilized to compare FOX03a expression of the decidual cells in uterine decidual stroma and cytotrophoblast-syncytiotrophoblast cells in placental villous stroma. Immunohistochemistry was evaluated semi-quantitatively utilizing the H-score technique. Results: It was demonstrated that H-Scores of FOX03a expression in both uterine decidual stroma were increased in the missed abortion group (255.83±12.41) than in the normal pregnancy group (133.33±17.43). It was also shown that there was no difference between non-decidual area of the endometrium of the normal pregnancy and the missed abortion group (30.33±4.32; 39.66±14.30, respectively) and placental villous stroma (13.00±1.89; 13.00±1.67, respectively). However, the immunoreactivity of cytotrophoblast and syncytiotrophoblast cells significantly increased in the missed abortion group (18.83±1.47; 322.00±6.06, respectively) than in the normal pregnancy group (11.00±1.26; 254.00±8.17, respectively) (p < 0.05). Conclusion: These data support the hypothesis that increased FOX03a expression in missed abortion may prevent the discharge of dead fetus to maintain decidualization, prevention of oxidative stress, immunomodulation, and inhibition of apoptosis.
dc.identifier.DOI-ID10.12891/ceog1911.2015
dc.identifier.issn03906663
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16523
dc.language.isoEnglish
dc.publisherS.O.G. CANADA Inc.
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAbortion, Missed
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectDecidua
dc.subjectEmbryo Implantation
dc.subjectFemale
dc.subjectForkhead Transcription Factors
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectPlacenta
dc.subjectPlacentation
dc.subjectPregnancy
dc.subjectPregnancy Trimester, First
dc.subjectYoung Adult
dc.subjectforkhead transcription factor
dc.subjectadult
dc.subjectapoptosis
dc.subjectArticle
dc.subjectchorion villus
dc.subjectclinical article
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectcytotrophoblast
dc.subjectdecidua
dc.subjectendometrium
dc.subjectfemale
dc.subjectfetus death
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunomodulation
dc.subjectimmunoreactivity
dc.subjectmissed abortion
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectplacenta
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectstroma
dc.subjectsyncytiotrophoblast
dc.subjectunwanted pregnancy
dc.subjectcase control study
dc.subjectdecidua
dc.subjectfirst trimester pregnancy
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectmissed abortion
dc.subjectnidation
dc.subjectplacenta
dc.subjectpregnancy
dc.subjectreproduction
dc.subjectyoung adult
dc.titleThe expression of forkhead transcription factors in decidua and placenta in patients with missed abortion
dc.typeArticle

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