Predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT

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dc.contributor.authorAras, F
dc.contributor.authorOlmezoglu, A
dc.date.accessioned2024-07-18T11:48:49Z
dc.date.available2024-07-18T11:48:49Z
dc.description.abstractOBJECTIVE: The objective of this study was to investigate predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT. PATIENTS AND METHODS: Overall, 94 early-stage non-small cell lung cancer (NSCLC) patients who were administered stereotactic radiotherapy were included in the study. RESULTS: Most of the study patients were male (91.5%). Mean age of the patients was 68.5 +/- 9.0 years. The primary lung tumor was located centrally and peripherally in 25 (26.6%) and 69 (73.4%) of the patients, respectively. The median gross tumor volume (GTV) was 16.2 cc [interquartile range (IQR): 7.1-32.9]. Whereas all patients who had peripheral tumors survived. 17 patients with central tumors (70.8%) died during the study period (p= 0.001). Biologically effective dose (BED10) values were significantly higher in patients who had peripheral tumors compared with patients with central tumors (p= 0.001). Significantly more patients died in patients who had BED values below 100 Gy compared to patients who had BED values over 100 Gy (p= 0.001). The survival distributions for the two groups were significantly different (p < 0.001). Only GTV and Pretreatment SUVmean appeared as significant predictors of mortality. BED10 values showed a significant and strong positive correlation with total radiation dose, whereas it showed a significant strong negative correlation with number of fractions. CONCLUSIONS: The use of repeated 18F-FDG PET to assess survival early during stereotactic radiotherapy is possible in patients with early-stage non-small cell lung cancer. A decrease in GTV and pretreatment SUVmean according to F-18 FDG PET/CT uptake by the primary tumor correlates with survival.
dc.identifier.issn1128-3602
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3552
dc.language.isoEnglish
dc.publisherVERDUCI PUBLISHER
dc.subjectBODY RADIATION-THERAPY
dc.subjectPATHOLOGICAL RESPONSE
dc.subjectABLATIVE RADIOTHERAPY
dc.subjectCHEMOTHERAPY
dc.subjectTOMOGRAPHY
dc.subjectCARCINOMA
dc.subjectSBRT
dc.titlePredictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT
dc.typeArticle

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