Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives

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dc.contributor.authorAlptuzun, V
dc.contributor.authorCakiroglu, G
dc.contributor.authorLimoncu, ME
dc.contributor.authorErac, B
dc.contributor.authorHosgor-Limoncu, M
dc.contributor.authorErciyas, E
dc.date.accessioned2024-07-18T11:54:07Z
dc.date.available2024-07-18T11:54:07Z
dc.description.abstractA series of substituted phenylethylidenehydrazinylpyridinium derivatives bearing methyl, ethyl, propyl, and propylphenyl groups on the pyridinium nitrogen were synthesized and evaluated for in vitro antileishmanial activity against Leishmania tropica by using the microdilution method. Among the tested compounds, 3d, 5c, 3b, and 3c were found to be the most active derivatives against the promastigotes of L. tropica (IC50 values are 6.90, 9.92, 11.69 and 12.03 mu M, respectively) and to be more active than reference drug meglumine antimonaite (glucantime) (IC50 value: 20.49 mu M). The derivatives investigated in this study may have the potential to be lead compound against leishmanial infection.
dc.identifier.issn1475-6366
dc.identifier.other1475-6374
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6122
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectLEISHMANIA-DONOVANI
dc.subjectIN-VITRO
dc.subjectTRYPANOTHIONE REDUCTASE
dc.subjectBIOLOGICAL-MEMBRANES
dc.subjectIMPROVED DELIVERY
dc.subjectPROMASTIGOTES
dc.subjectCHEMOTHERAPY
dc.subjectINHIBITOR
dc.subjectBINDING
dc.subjectDESIGN
dc.titleSynthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives
dc.typeArticle

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