Evaluation of 131I-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters

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dc.contributor.authorInceboz, T
dc.contributor.authorLambrecht, FY
dc.contributor.authorEren, MS
dc.contributor.authorGirginkardesler, N
dc.contributor.authorBekis, R
dc.contributor.authorYilmaz, O
dc.contributor.authorEr, Ö
dc.contributor.authorÖzbilgin, A
dc.date.accessioned2024-07-18T12:03:34Z
dc.date.available2024-07-18T12:03:34Z
dc.description.abstractWe aimed to assess the ability of I-131-Pentamidine scintigraphy to detect the lesions of Leishmania tropica infection. An experimental model of cutaneous leishmaniasis was developed. The presence of cutaneous leishmaniasis was confirmed. Pentamidine was radioiodinated with I-131. The radiolabeled pentamidine was validated by the requisite quality control tests to check its radiolabeling efficiency, in vitro stability. I-131-Pentamidine (activity: 18.5 MBq/100 mu l) was injected intracardiacally into infected hamsters. Static whole body images of the hamsters were acquired under the gamma camera at 5 and 30 min, 2, 6 and 24 h following the administration. On the scintigrams, anatomically adjusted regions of interest (ROIs) were drawn over the right feet (target) and left feet (not-target) and various organs. Accumulation of I-131-Pentamidine at sites of infection is expressed as the target to non-target (T/NT) ratio. The results T/NT ratio decreased with time. In concluding the I-131-Pentamidine has poor sensitivity in detection of L. tropica infection.
dc.identifier.issn1061-186X
dc.identifier.other1029-2330
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9214
dc.language.isoEnglish
dc.publisherINFORMA HEALTHCARE
dc.subjectCUTANEOUS LEISHMANIASIS
dc.subjectPENTAMIDINE
dc.subjectRATS
dc.subjectBIODISTRIBUTION
dc.subjectLESIONS
dc.titleEvaluation of 131I-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters
dc.typeArticle

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