Bladder Function Recovery in Rats With Traumatic Spinal Cord Injury After Transplantation of Neuronal-Glial Restricted Precursors or Bone Marrow Stromal Cells

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dc.contributor.authorTemeltas, G
dc.contributor.authorDagci, T
dc.contributor.authorKurt, F
dc.contributor.authorEvren, V
dc.contributor.authorTuglu, I
dc.date.accessioned2024-07-18T12:02:40Z
dc.date.available2024-07-18T12:02:40Z
dc.description.abstractPurpose: We investigated functional recovery of the lower urinary system in rats with spinal cord injury after transplanting neuronal restricted precursors/glial restricted precursors or neural cells derived from bone marrow stromal cells into the injured area of the spinal cord. Materials and Methods: A total of 30 rats underwent experimentation in 4 groups, including group 1-sham operation, group 2-spinal cord injury plus neuronal restricted precursor/glial restricted precursor transplantation, group 3-spinal cord injury plus bone marrow stromal cell transplantation and group 4-spinal cord injury control. All rats in the 4 groups were investigated urodynamically and sacrificed on day 28 after transplantation. The cells transplanted into the injured spinal cord underwent histological investigation. Results: Transplanted cells (neuronal and glial restricted precursors, and bone marrow stromal cells) were found to maintain a presence in the injured spinal cord area. Baseline pressure, maximum capacity, mean uninhibited contraction amplitude, mean voiding pressure, voided volume and post-void residual volume were significantly better in groups 2 and 3 than in group 4, while baseline pressure in group 2 was better than that in group 3. We found no significant difference among the groups according to mean uninhibited contraction frequency. Conclusions: Although neuronal/glial restricted precursor transplanted rats seemed to have more improvement, all rats in groups 2 and 3 showed some significant improvement in lower urinary system function. On the other hand, the level of this improvement was far from complete functional recovery.
dc.identifier.issn0022-5347
dc.identifier.other1527-3792
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8583
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectDIFFERENTIATE
dc.titleBladder Function Recovery in Rats With Traumatic Spinal Cord Injury After Transplantation of Neuronal-Glial Restricted Precursors or Bone Marrow Stromal Cells
dc.typeArticle

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