Short report: Quantiferon-Leishmania as an epidemiological tool for evaluating the exposure to Leishmania infection
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Date
2010
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Abstract
The aim of the present preliminary study was to investigate the potential of measurement of IFN-γ secretion by T cells into blood plasma using QuantiFERON assay with leishmanial antigens to determine the presence of Leishmania infection. Blood samples from cured visceral (N = 18), and cutaneous (N = 20) leishmaniasis cases, and 20 healthy controls were tested. The IFN-γ responses to Leishmania major H2B and Leishmania infantum H2B antigens were detected from the majority of treated old visceral leishmaniasis cases, but not from controls. Future studies using larger groups will be required to establish the true potential of the assay for epidemiological screening of leishmaniasis. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
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Keywords
Antigens, Protozoan , Humans , Interferon-gamma , Leishmania , Leishmaniasis , Sensitivity and Specificity , Serologic Tests , T-Lymphocytes , Leishmania infantum , Leishmania major , gamma interferon , leishmanial antigen , parasite antigen , unclassified drug , gamma interferon , leishmanin , parasite antigen , article , blood sampling , clinical article , controlled study , cytokine release , diagnostic test , human , Leishmania infantum , Leishmania major , leishmaniasis , quantiferon assay , sensitivity and specificity , T lymphocyte , blood , immunology , Leishmania , leishmaniasis , secretion , serology