Short report: Quantiferon-Leishmania as an epidemiological tool for evaluating the exposure to Leishmania infection

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dc.contributor.authorTurgay N.
dc.contributor.authorBalcioglu I.C.
dc.contributor.authorToz S.O.
dc.contributor.authorOzbel Y.
dc.contributor.authorJones S.L.
dc.date.accessioned2024-07-22T08:20:43Z
dc.date.available2024-07-22T08:20:43Z
dc.date.issued2010
dc.description.abstractThe aim of the present preliminary study was to investigate the potential of measurement of IFN-γ secretion by T cells into blood plasma using QuantiFERON assay with leishmanial antigens to determine the presence of Leishmania infection. Blood samples from cured visceral (N = 18), and cutaneous (N = 20) leishmaniasis cases, and 20 healthy controls were tested. The IFN-γ responses to Leishmania major H2B and Leishmania infantum H2B antigens were detected from the majority of treated old visceral leishmaniasis cases, but not from controls. Future studies using larger groups will be required to establish the true potential of the assay for epidemiological screening of leishmaniasis. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
dc.identifier.DOI-ID10.4269/ajtmh.2010.09-0605
dc.identifier.issn00029637
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18275
dc.language.isoEnglish
dc.rightsAll Open Access; Green Open Access
dc.subjectAntigens, Protozoan
dc.subjectHumans
dc.subjectInterferon-gamma
dc.subjectLeishmania
dc.subjectLeishmaniasis
dc.subjectSensitivity and Specificity
dc.subjectSerologic Tests
dc.subjectT-Lymphocytes
dc.subjectLeishmania infantum
dc.subjectLeishmania major
dc.subjectgamma interferon
dc.subjectleishmanial antigen
dc.subjectparasite antigen
dc.subjectunclassified drug
dc.subjectgamma interferon
dc.subjectleishmanin
dc.subjectparasite antigen
dc.subjectarticle
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytokine release
dc.subjectdiagnostic test
dc.subjecthuman
dc.subjectLeishmania infantum
dc.subjectLeishmania major
dc.subjectleishmaniasis
dc.subjectquantiferon assay
dc.subjectsensitivity and specificity
dc.subjectT lymphocyte
dc.subjectblood
dc.subjectimmunology
dc.subjectLeishmania
dc.subjectleishmaniasis
dc.subjectsecretion
dc.subjectserology
dc.titleShort report: Quantiferon-Leishmania as an epidemiological tool for evaluating the exposure to Leishmania infection
dc.typeArticle

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