The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

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dc.contributor.authorInan, SY
dc.contributor.authorAksu, F
dc.contributor.authorBaysal, F
dc.date.accessioned2024-07-18T12:00:19Z
dc.date.available2024-07-18T12:00:19Z
dc.description.abstractThe effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shuck reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shuck in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. (C) 2000 Elsevier Science B.V. All rights reserved.
dc.identifier.issn0014-2999
dc.identifier.other1879-0712
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7629
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE BV
dc.subjectPOTASSIUM CHANNELS
dc.subjectLESIONED MICE
dc.subjectMEMORY
dc.subjectAPAMIN
dc.subjectRATS
dc.subject3,4-DIAMINOPYRIDINE
dc.subjectACETYLCHOLINE
dc.subjectPERFORMANCE
dc.subjectHABITUATION
dc.subjectMAZE
dc.titleThe effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice
dc.typeArticle

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