Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features
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Date
2014
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Abstract
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
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Adult , Aged , Female , Humans , Intercellular Signaling Peptides and Proteins , Lymphatic Metastasis , Lymphatic Vessels , Male , Middle Aged , Neoplasm Invasiveness , Tumor Burden , Tumor Markers, Biological , Turkey , Urinary Bladder Neoplasms , DKK1 protein, human , signal peptide , tumor marker , adult , aged , article , bladder tumor , blood , female , human , lymph node metastasis , lymph vessel , male , middle aged , pathology , tumor invasion , tumor volume , Turkey (republic)