Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features

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dc.contributor.authorKaba M.
dc.contributor.authorPirincci N.
dc.contributor.authorBenli E.
dc.contributor.authorGecit I.
dc.contributor.authorGunes M.
dc.contributor.authorYuksel M.B.
dc.contributor.authorTok A.
dc.contributor.authorKemik A.S.
dc.date.accessioned2024-07-22T08:17:13Z
dc.date.available2024-07-22T08:17:13Z
dc.date.issued2014
dc.description.abstractBackground: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
dc.identifier.DOI-ID10.7314/APJCP.2014.15.1.381
dc.identifier.issn15137368
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16979
dc.language.isoEnglish
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectLymphatic Metastasis
dc.subjectLymphatic Vessels
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectTumor Burden
dc.subjectTumor Markers, Biological
dc.subjectTurkey
dc.subjectUrinary Bladder Neoplasms
dc.subjectDKK1 protein, human
dc.subjectsignal peptide
dc.subjecttumor marker
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbladder tumor
dc.subjectblood
dc.subjectfemale
dc.subjecthuman
dc.subjectlymph node metastasis
dc.subjectlymph vessel
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpathology
dc.subjecttumor invasion
dc.subjecttumor volume
dc.subjectTurkey (republic)
dc.titleDickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features
dc.typeArticle

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