Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion

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dc.contributor.authorTemiz, C
dc.contributor.authorDogan, A
dc.contributor.authorBaskaya, MK
dc.contributor.authorDempsey, RJ
dc.date.accessioned2024-07-18T12:06:28Z
dc.date.available2024-07-18T12:06:28Z
dc.description.abstractPolyamines have been shown to play an important role in the disturbance of the blood-brain barrier (BBB) in a number of pathological states including ischemia. BIBB disturbances may be almost completely prevented by treating animals with the ornithine decarboxylase (ODC) inhibitor, alpha-difluoromethylornithine (DFMO). DFMO has been also shown to prevent N-Methyl-D-aspartate (NMDA) toxicity in tissue cultures. It has been suggested that the pathological disturbances in polyamine metabolism observed following cerebral ischemia, particularly the post-ischemic increase in putrescine, may contribute to the ischemic injury that is most evident in the CA1 subfield of the hippocampus. In this study, effects of DFMO in cerebral ischemia and reperfusion were examined. The results showed that inhibition of the polyamine system by DFMO decreased ischemic injury volume and brain tissue water content in a dose-dependent manner, without change in vital signs, including systemic arterial blood pressure, arterial partial oxygen pressure, regional cerebral blood flow and body temperature. (c) 2005 Published by Elsevier Ltd.
dc.identifier.issn0967-5868
dc.identifier.other1532-2653
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10409
dc.language.isoEnglish
dc.publisherELSEVIER SCI LTD
dc.subjectBLOOD-BRAIN-BARRIER
dc.subjectORNITHINE DECARBOXYLASE ACTIVITY
dc.subjectDEVELOPING RAT-BRAIN
dc.subjectALPHA-DIFLUOROMETHYLORNITHINE
dc.subjectPOLYAMINE METABOLISM
dc.subjectMONGOLIAN GERBILS
dc.subjectISCHEMIA
dc.subjectPERMEABILITY
dc.subjectEDEMA
dc.subjectSTIMULATION
dc.titleEffect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion
dc.typeArticle

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