A new dressing material in diabetic wounds: Wound healing activity of oleuropein-rich olive leaf extract in diabetic rats

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dc.contributor.authorSamancioglu, S
dc.contributor.authorEsen, A
dc.contributor.authorErcan, G
dc.contributor.authorMansoub, NH
dc.contributor.authorVatansever, S
dc.contributor.authorInce, I
dc.date.accessioned2024-07-18T12:03:33Z
dc.date.available2024-07-18T12:03:33Z
dc.description.abstractIntroduction: The objective of this study was to evaluate a dressing material on ischemic wound model in diabetic rats. Study was conducted during the months of June 2012-March 2013 at Ege University in Izmir, Turkey. Materials and Methods: Sprague Dawley rats weighing 200-250 g obtained from an experimental animal production center (Saki Yenili-Ankara,Turkey) were used in this study. Animals were randomly assigned to diabetic (n= 20) and nondiabetic (n= 20) groups. After diabetes induction and wound creation, animals within each group were assigned to two wound dressing groups by a second randomization. The study was carried out on these four groups. After diabetes induction and wound creation, animals within each group (n= 10) were assigned to olive leaf extract (OLE) wound dressing and normal saline (sodium chloride, 0.9% NaCI) wound dressing groups by a second randomization. 0.9% NaCl and OLE dressing was applied to wounds once a day by the researcher. The areas of wounds were measured by Walker Formula. OLE wound dressing healed wounds faster and earlier than classic wound dressing (p< 0.05). Results: In the diabetic group; wounds closure time was found to be 24.80 +/- 1.48 in OLE wound dressing and 28.00 +/- 2.31 days in classical wound dressing. Conclusion: As a result in terms of success ratios, OLE wound dressing for wound healing in diabetic and non-diabetic wounds has been determined to be more effective in comparison with classic wound dressing method.
dc.identifier.issn2564-7784
dc.identifier.other2564-7040
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9189
dc.language.isoEnglish
dc.publisherAVES
dc.subjectMEDICINAL-PLANTS
dc.subjectPLASMA
dc.subjectWILD
dc.titleA new dressing material in diabetic wounds: Wound healing activity of oleuropein-rich olive leaf extract in diabetic rats
dc.typeArticle

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