Evaluation of the Pol/S gene overlapping mutations in chronic hepatitis B patients in northern Cyprus
| dc.contributor.author | Arikan A. | |
| dc.contributor.author | Sayan M. | |
| dc.contributor.author | Sanlidag T. | |
| dc.contributor.author | Suer K. | |
| dc.contributor.author | Akcali S. | |
| dc.contributor.author | Guvenir M. | |
| dc.date.accessioned | 2025-04-10T11:07:35Z | |
| dc.date.available | 2025-04-10T11:07:35Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Mutations associated with the pol and the S gene can emerge as a consequence of the high replication capacity and proofreading deficiencies of hepatitis B virus during replication. The current study was constructed to evaluate primary, partial, compensatory and the escape mutations in chronic hepatitis B patients in Northern Cyprus. The samples of HBsAg positive treatment naïve 100 patients were involved in this study. HBV pol gene region was sequenced, amplified and HBV pol/S gene mutations were determined. The samples of thirty-two patients were excluded because of their low viral load (HBV < 1000 ıu/ml). Among the sequenced 68 samples, there was a partial mutation (1.5%) and 36.7% displayed a resistance profile to lamivudine, adevofir, and telbivudine. Immune response escape, vaccine escape, HBIg and diagnosis escape mutations were determined in 24%, 10%, 6%, and 4% samples of the patients, respectively. Additionally, there were six different combined mutations. These data underscored that there is no concern for primary mutations in Northern Cyprus, however, we have identified a compensatory mutation (rtV173M) that may have primary mutation characteristics by combining with other mutation patterns. Additionally, HBsAg escape mutants demonstrated that detection of the S gene together with the pol gene mutations might be beneficial and important to monitor the surveillance of S variants. © 2019 Ayse Arikan et al. | |
| dc.identifier.DOI-ID | 10.33073/pjm-2019-034 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/47478 | |
| dc.publisher | Polish Society of Microbiologists | |
| dc.title | Evaluation of the Pol/S gene overlapping mutations in chronic hepatitis B patients in northern Cyprus | |
| dc.type | Article |