Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure

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dc.contributor.authorBecer E.
dc.contributor.authorKabadayı H.
dc.contributor.authorBaşer K.H.C.
dc.contributor.authorVatansever H.S.
dc.date.accessioned2025-04-10T11:06:02Z
dc.date.available2025-04-10T11:06:02Z
dc.date.issued2021
dc.description.abstractBoswellia sacra Flueck essential oil is obtained from frankincense obtained from Boswellia sacra trees. The aim of this study was to investigate the in vitro anti-cancer activity of Boswellia sacra (BS) essential oil in CD133+ and CD133- Colo-320 cells. Essential oil was analyzed by GC-MS. CD133+ cells, cancer stem cells, were obtained from the Colo-320 by the MiniMACS system. Cytotoxicity were evaluated with MTT assay. Anti-cancer activity of BS essential oil was investigated by immunocytochemistry. 41 compounds were identified in the essential oil. 1:2 dilution BS essential oil was found to be active against all the cells for 24 h incubation. β-catenin immunoreactivity was significantly decreased in both BS essential oil-treated CD133+ and CD133- Colo-320 cells. Caspase-3 immunoreactivity significantly increased in BS essential oil-treated CD133- Colo-320 cells. We conclude that BS essential oil decreased β-catenin signaling molecules which play a crucial role in cancer cell proliferation. BS essential oil promoted apoptosis in CD133- Colo-320 cells. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/10412905.2020.1839586
dc.identifier.urihttp://hdl.handle.net/20.500.14701/46435
dc.publisherBellwether Publishing, Ltd.
dc.titleBoswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure
dc.typeArticle

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