Cutoff Values of MASK-air Patient-Reported Outcome Measures

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dc.contributor.authorSousa-Pinto, B
dc.contributor.authorSa-Sousa, A
dc.contributor.authorVieira, RJ
dc.contributor.authorAmaral, R
dc.contributor.authorPereira, AM
dc.contributor.authorAnto, JM
dc.contributor.authorKlimek, L
dc.contributor.authorCzarlewski, W
dc.contributor.authorMullol, J
dc.contributor.authorPfaar, O
dc.contributor.authorBedbrook, A
dc.contributor.authorBrussino, L
dc.contributor.authorKvedariene, V
dc.contributor.authorLarenas-Linnemann, DE
dc.contributor.authorOkamoto, Y
dc.contributor.authorVentura, MT
dc.contributor.authorAnsotegui, IJ
dc.contributor.authorBosnic-Anticevich, S
dc.contributor.authorCanonica, GW
dc.contributor.authorCardona, V
dc.contributor.authorCecchi, L
dc.contributor.authorChivato, T
dc.contributor.authorCingi, C
dc.contributor.authorCosta, EM
dc.contributor.authorCruz, AA
dc.contributor.authorDel Giacco, S
dc.contributor.authorDevillier, P
dc.contributor.authorFokkens, WJ
dc.contributor.authorGemicioglu, B
dc.contributor.authorHaahtela, T
dc.contributor.authorIvancevich, JC
dc.contributor.authorKuna, P
dc.contributor.authorKaidashev, I
dc.contributor.authorKraxner, H
dc.contributor.authorLaune, D
dc.contributor.authorLouis, R
dc.contributor.authorMakris, M
dc.contributor.authorMonti, R
dc.contributor.authorMorais-Almeida, M
dc.contributor.authorMosges, R
dc.contributor.authorNiedoszytko, M
dc.contributor.authorPapadopoulos, NG
dc.contributor.authorPatella, V
dc.contributor.authorPham-Thi, N
dc.contributor.authorRegateiro, FS
dc.contributor.authorReitsma, S
dc.contributor.authorRouadi, PW
dc.contributor.authorSamolinski, B
dc.contributor.authorSheikh, A
dc.contributor.authorSova, M
dc.contributor.authorTaborda-Barata, L
dc.contributor.authorToppila-Salmi, S
dc.contributor.authorSastre, J
dc.contributor.authorTsiligianni, I
dc.contributor.authorValiulis, A
dc.contributor.authorYorgancioglu, A
dc.contributor.authorZidarn, M
dc.contributor.authorZuberbier, T
dc.contributor.authorFonseca, JA
dc.contributor.authorBousquet, J
dc.date.accessioned2024-07-18T12:08:59Z
dc.date.available2024-07-18T12:08:59Z
dc.description.abstractBACKGROUND: In clinical and epidemiological studies, cutoffs of patient-reported outcome measures can be used to classify patients into groups of statistical and clinical relevance. However, visual analog scale (VAS) cutoffs in MASK-air have not been tested. OBJECTIVE: To calculate cutoffs for VAS global, nasal, ocular, and asthma symptoms.METHODS: In a cross-sectional study design of all MASK-air participants, we compared (1) approaches based on the percen-tiles (tertiles or quartiles) of VAS distributions and (2) data -driven approaches based on clusters of data from 2 comparators (VAS work and VAS sleep). We then performed sensitivityanalyses for individual countries and for VAS levels corre-sponding to full allergy control. Finally, we tested the different approaches using MASK-air real-world cross-sectional and lon-gitudinal data to assess the most relevant cutoffs.RESULTS: We assessed 395,223 days from 23,201 MASK-air users with self-reported allergic rhinitis. The percentile-oriented approach resulted in lower cutoff values than the data-driven approach. We obtained consistent results in the data-driven approach. Following the latter, the proposed cutoff differenti-ating controlled and partly-controlled patients was similar to the cutoff value that had been arbitrarily used (20/100). However, a lower cutoff was obtained to differentiate between partly-controlled and uncontrolled patients (35 vs the arbitrarily-used value of 50/100).CONCLUSIONS: Using a data-driven approach, we were able to define cutoff values for MASK-air VASs on allergy and asthma symptoms. This may allow for a better classification of patients with rhinitis and asthma according to different levels of control, supporting improved disease management. (c) 2022 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1281-9)
dc.identifier.issn2213-2198
dc.identifier.other2213-2201
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11099
dc.language.isoEnglish
dc.publisherELSEVIER
dc.subjectPERSON-CENTERED CARE
dc.subjectALLERGIC RHINITIS
dc.subjectSEVERITY
dc.subjectASTHMA
dc.subjectSLEEP
dc.titleCutoff Values of MASK-air Patient-Reported Outcome Measures
dc.typeArticle

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