Effect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum

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dc.contributor.authorGöçmen C.
dc.contributor.authorGöktürk H.S.
dc.contributor.authorErtuǧ P.U.
dc.contributor.authorÖnder S.
dc.contributor.authorDikmen A.
dc.contributor.authorBaysal F.
dc.date.accessioned2024-07-22T08:25:40Z
dc.date.available2024-07-22T08:25:40Z
dc.date.issued2000
dc.description.abstractThe effects of neocuproine and bathocuproine, Cu(I) and Cu(II) chelators, respectively, were studied on relaxations in response to electrical field stimulation, acetylcholine, S-nitrosoglutathione, acidified sodium nitrite and sodium nitroprusside in the mouse corpus cavernosum precontracted with phenylephrine. Neocuproine significantly inhibited relaxations induced by electrical field stimulation, acetylcholine and S- nitrosoglutathione, but not by acidified sodium nitrite and sodium nitroprusside. The pre-prepared neocuproine-Cu(I) complex was ineffective on the responses. The discrepancy between the shape of relaxations in response to electrical field stimulation or to acetylcholine and S-nitrosoglutathione was abolished by adding CuCl2 into the bathing medium. The copper action was blocked by neocuproine but not by bathocuproine. However, the pre-prepared bathocuproine-Cu(II) complex did not accelerate the relaxations affected by CuCl2. These findings suggest that a Cu(I)-dependent mechanism may play a role in the relaxation induced by the endogenous relaxant factor as well as by S-nitrosoglutathione in mouse cavernosal tissue. (C) 2000 Elsevier Science B.V.
dc.identifier.DOI-ID10.1016/S0014-2999(00)00657-9
dc.identifier.issn00142999
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20542
dc.language.isoEnglish
dc.subjectAcetylcholine
dc.subjectAnimal
dc.subjectChelating Agents
dc.subjectCopper
dc.subjectDose-Response Relationship, Drug
dc.subjectElectric Stimulation
dc.subjectGlutathione
dc.subjectMale
dc.subjectMice
dc.subjectNitric Oxide
dc.subjectNitroprusside
dc.subjectNitroso Compounds
dc.subjectPenis
dc.subjectPhenanthrolines
dc.subjectPhenylephrine
dc.subjectS-Nitrosoglutathione
dc.subjectSupport, Non-U.S. Gov't
dc.subject2,9 dimethyl 1,10 phenanthroline
dc.subjectacetylcholine
dc.subjectchelating agent
dc.subjectcopper chloride
dc.subjectcopper ion
dc.subjectnitroprusside sodium
dc.subjectphenylephrine
dc.subjects nitrosoglutathione
dc.subjectsodium nitrite
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectchelation
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectelectrostimulation
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsignal transduction
dc.subjectsmooth muscle relaxation
dc.titleEffect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum
dc.typeArticle

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