Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients

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dc.contributor.authorEker, C
dc.contributor.authorKitis, O
dc.contributor.authorTaneli, F
dc.contributor.authorEker, OD
dc.contributor.authorOzan, E
dc.contributor.authorYucel, K
dc.contributor.authorCoburn, K
dc.contributor.authorGonul, AS
dc.date.accessioned2024-07-18T12:06:11Z
dc.date.available2024-07-18T12:06:11Z
dc.description.abstractThe hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF) levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 +/- A 9.3) and healthy controls (17 female, 5 male; mean age = 29.7 +/- A 6.4). Region of interest analysis was conducted on the images acquired via MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent as severe and multiple episodes are experienced.
dc.identifier.issn0940-1334
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10251
dc.language.isoEnglish
dc.publisherSPRINGER HEIDELBERG
dc.subjectNEUROTROPHIC FACTOR LEVELS
dc.subjectMAJOR DEPRESSION
dc.subjectBRAIN
dc.subjectDISORDER
dc.subjectSTRESS
dc.subjectAMYGDALA
dc.subjectTRAUMA
dc.subjectMRI
dc.titleCorrelation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients
dc.typeArticle

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