The Effects of Meloxicam on Neural Tube Development in the Early Stage of Chick Embryos

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dc.contributor.authorCetinkal, A
dc.contributor.authorColak, A
dc.contributor.authorTopuz, K
dc.contributor.authorDemircan, MN
dc.contributor.authorSimsek, H
dc.contributor.authorBerber, U
dc.contributor.authorUmur, AS
dc.contributor.authorSelcuki, M
dc.contributor.authorVatansever, HS
dc.date.accessioned2024-07-18T12:03:20Z
dc.date.available2024-07-18T12:03:20Z
dc.description.abstractAIM: The aim of this study is to demonstrate the effect of meloxicam in early stage chick embryos on neural tube development. MATERIAL and METHODS: One hundred specific pathogen-free (SPF) chicken eggs were used to investigate the neurulation. SPF eggs were invastigated in four groups (n:25). All of the groups were incubated at 37.2 +/- 0.1 degrees C and 60 +/- 5% relative humidity for 30 hours, and an embryological development in the ninth stage as classified by Hamburger and Hamilton was obtained. In the end of the 30th hour, group A (control group) was administered 0.1 ml of saline (0.9% NaCl) in ovo and the other groups were administered meloxicam in increasing doses. At the end of 72 hours, all of the embryos were extracted from eggs and they underwent pathological examination with hematoxylin cosine and immuno-histopathological examinations with CD138 and tubulin beta II. RESULTS: While the groups A and B showed no neural tube defects, totally eight defective embryos were detected in the groups C and D (three in group C and five in group D. CONCLUSION: Our results suggested that meloxicam, a nonselective COX inhibitor, caused neural tube closure defects when injected at supratherapeutic doses. However, further studies with larger numbers of subjects are needed for its use in lower doses.
dc.identifier.issn1019-5149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9058
dc.language.isoEnglish
dc.publisherTURKISH NEUROSURGICAL SOC
dc.subjectFETAL ALCOHOL SYNDROME
dc.subjectCLOSURE DEFECTS
dc.subjectFOLIC-ACID
dc.subjectCELL-DEATH
dc.subjectETHANOL
dc.subjectNEURULATION
dc.subjectTERATOGENICITY
dc.subjectPHENYTOIN
dc.titleThe Effects of Meloxicam on Neural Tube Development in the Early Stage of Chick Embryos
dc.typeArticle

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