Preparation, in vitro mineralization and osteoblast cell response of electrospun 13-93 bioactive glass nanofibers

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dc.contributor.authorDeliormanli, AM
dc.date.accessioned2024-07-18T11:39:31Z
dc.date.available2024-07-18T11:39:31Z
dc.description.abstractIn this study, silicate based 13-93 bioactive glass fibers were prepared through sol-gel processing and electrospinning technique. A precursor solution containing poly (vinyl alcohol) and bioactive glass sol was used to produce fibers. The mixture was electrospun at a voltage of 20 kV by maintaining tip to a collector distance of 10 cm. The amorphous glass fibers with an average diameter of 464 +/- 95 nm were successfully obtained after calcination at 625 degrees C. Hydroxyapatite formation on calcined 13-93 fibers was investigated in simulated body fluid (SBF) using two different fiber concentrations (0.5 and 1 mg/ml) at 37 degrees C. When immesed in SBF, conversion to a calcium phosphate material showed a strong dependence on the fiber concentration. At 1 mg/ml, the surface of the fibers converted to the hydroxyapatite-like material in SBF only after 30 days. At lower solid concentrations (0.5 mg/ml), an amorphous calcium phosphate layer formation was observed followed by the conversion to hydroxyapatite phase after 7 days of immersion. The XIT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfopheny1)-2H-Tetrazolium-5-Carboxanilide) assay was conducted to evaluate the osteoblast cell response to the bioactive glass fibers. (C) 2015 Elsevier B.V. All rights reserved.
dc.identifier.issn0928-4931
dc.identifier.other1873-0191
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/1678
dc.language.isoEnglish
dc.publisherELSEVIER
dc.subjectCERAMIC NANOFIBERS
dc.subjectSCAFFOLDS
dc.subjectPOLYCAPROLACTONE
dc.subjectSURFACTANTS
dc.titlePreparation, in vitro mineralization and osteoblast cell response of electrospun 13-93 bioactive glass nanofibers
dc.typeArticle

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