Simultaneous determination of six antibiotics belonging to four different classes in chicken meat BY HPLC/DAD and verification BY LC-MS/MS

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dc.contributor.authorDoyuk F.
dc.contributor.authorDost K.
dc.date.accessioned2024-07-22T08:02:18Z
dc.date.available2024-07-22T08:02:18Z
dc.date.issued2023
dc.description.abstractThe hypothesis of this study was to develop an extraction method allowing side-by-side extraction of six antibiotics belonging to four different classes and an HPLC/DAD method for the determination of their residues in chicken breast meat. The validation data showed that this hypothesis was achieved. The results were then confirmed by LC-MS/MS method. Sample preparation was based on the classical solid–liquid extraction with methanolic citric acid. The average recoveries were satisfactory and ranged from 75.68 to 101.3%. The linearity of the developed HPLC/DAD method was very high in the concentration range studied (R2 > 0.9969). The accuracy and precision of the analytical method were between –10.8 and 12.0% relative error and 0.82 to 10.1% relative standard deviation, respectively. The LODs for five antibiotics ranged from 0.6 to 2.7 µg kg−1 and LOQs ranged from 2.0 to 8.9 µg kg−1. For penicillin G, the LOD was 0.16 and LOQ was 0.52 mg kg−1. © 2023 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.foodchem.2023.136549
dc.identifier.issn03088146
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11778
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectChickens
dc.subjectChromatography, High Pressure Liquid
dc.subjectChromatography, Liquid
dc.subjectMeat
dc.subjectTandem Mass Spectrometry
dc.subjectAnimals
dc.subjectExtraction
dc.subjectMeats
dc.subjectantibiotic agent
dc.subjectchloramphenicol
dc.subjectchlortetracycline
dc.subjectcitric acid
dc.subjectenrofloxacin
dc.subjectfood additive
dc.subjectoxytetracycline
dc.subjectpenicillin G
dc.subjecttetracycline
dc.subjectantiinfective agent
dc.subjectChicken meat
dc.subjectChloramphenicol
dc.subjectDifferent class
dc.subjectEnrofloxacin
dc.subjectExtraction method
dc.subjectHplc/dad
dc.subjectLC-MS-MS
dc.subjectPenicillin G
dc.subjectSimultaneous determinations
dc.subjectTetracycline
dc.subjectaccuracy
dc.subjectanalytic method
dc.subjectanalytical parameters
dc.subjectanimal experiment
dc.subjectanimal food
dc.subjectArticle
dc.subjectbreast
dc.subjectchemical structure
dc.subjectchicken meat
dc.subjectchromatography
dc.subjectconcentration (parameter)
dc.subjectcontrolled study
dc.subjectextraction
dc.subjectGallus gallus
dc.subjecthigh performance liquid chromatography
dc.subjecthypothesis
dc.subjectlimit of detection
dc.subjectlimit of quantitation
dc.subjectliquid chromatography-mass spectrometry
dc.subjectmass spectrometry
dc.subjectmatrix effect
dc.subjectnonhuman
dc.subjectpoultry farming
dc.subjectretention time
dc.subjecttemperature
dc.subjecttoxicity
dc.subjectanimal
dc.subjectGallus gallus
dc.subjecthigh performance liquid chromatography
dc.subjectliquid chromatography
dc.subjectmeat
dc.subjectprocedures
dc.subjecttandem mass spectrometry
dc.subjectAntibiotics
dc.titleSimultaneous determination of six antibiotics belonging to four different classes in chicken meat BY HPLC/DAD and verification BY LC-MS/MS
dc.typeArticle

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