Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia

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dc.contributor.authorErcan E.
dc.contributor.authorTengiz I.
dc.contributor.authorAltuglu I.
dc.contributor.authorSekuri C.
dc.contributor.authorAliyev E.
dc.contributor.authorErcan H.E.
dc.contributor.authorAkin M.
dc.date.accessioned2025-04-10T11:17:43Z
dc.date.available2025-04-10T11:17:43Z
dc.date.issued2004
dc.description.abstractBackground. Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response. Aim. To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity. Methods. In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later. Results. Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9±26.6 to 94.5±20.8 mg/dl, p<0.005) in the atorvastatin group and by 9% in the diet alone group. Atorvastatin lowered plasma CRP from 5.16±1.9 to 2.88±1.06 mg/L (p<0.001) and MMP-9 activity from 64.3±28.1 to 35.4±20.0 ng/ml (p<0.0001). Atorvastatin-induced reductions in CRP and MMP-9 were greater than in the diet alone group. MMP-9 levels did not show significant changes in Group 2 after two months of diet. Conclusions. Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia.
dc.identifier.urihttp://hdl.handle.net/20.500.14701/52892
dc.publisherKlinika Kardiologii CMKP
dc.titleAtorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia
dc.typeArticle

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