Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study

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dc.contributor.authorMalkoc, G
dc.contributor.authorDalgic, A
dc.contributor.authorKoc, M
dc.contributor.authorKandogan, T
dc.contributor.authorKorkmaz, S
dc.contributor.authorCeylan, ME
dc.contributor.authorInan, S
dc.contributor.authorOlgun, L
dc.date.accessioned2024-07-18T12:00:44Z
dc.date.available2024-07-18T12:00:44Z
dc.description.abstractObjective: This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application. Method: The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 mu g/ml dexamethasone. Results: Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone. Conclusion: The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma.
dc.identifier.issn0022-2151
dc.identifier.other1748-5460
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7932
dc.language.isoEnglish
dc.publisherCAMBRIDGE UNIV PRESS
dc.subjectCOCHLEAR IMPLANTATION TRAUMA
dc.subjectHEARING-LOSS
dc.subjectEXPRESSION
dc.subjectMODEL
dc.subjectPROTECTS
dc.subjectGENES
dc.titleHistopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study
dc.typeArticle

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