Construction of Hexahydropyrido[3,2-c]carbazole and Hexahydropyrrolo[3,2-c]carbazole Skeletons for the Synthesis of Related Indole Alkaloids
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Abstract
Synthesis of tetracyclic hexahydropyrido[3,2-[c] carbazoles (9a and 9b) and hexahydropyrrolo[3,2-[c]carbazoles (13a and 13b) structures was achieved via a new synthetic approach for the synthesis of related indole alkaloids such as deethylaspidospermidine and deethylibophyllidine. Hexahydropyrrolo[3,2-[c] carbazole structure was constructed for the first time starting from ethyl 4-[oxo-[cyclohexanecarboxylate in seven steps. Some tetrahydrocarbazole derivatives (4, 5, 6, 7, 11, and 12) were also synthesized.