The effect of resveratrol on the histologic characteristics of the cochlea in diabetic rats

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dc.contributor.authorErkan S.O.
dc.contributor.authorTuhanioğlu B.
dc.contributor.authorGürgen S.G.
dc.contributor.authorÖzdaş T.
dc.contributor.authorTaştekin B.
dc.contributor.authorPelit A.
dc.contributor.authorGörgülü O.
dc.date.accessioned2024-07-22T08:09:09Z
dc.date.available2024-07-22T08:09:09Z
dc.date.issued2019
dc.description.abstractObjectives/Hypothesis: The aim of this study was to investigate changes in the cochlea and the potential dose-dependent effects of resveratrol (RSV) against diabetes mellitus (DM) ototoxicity. Study Design: Animal model. Methods: Twenty-four male Wistar albino rats were divided into four groups. Baseline distortion product otoacoustic emission (DPOAE) measurements were evaluated. Group I was the control group, group II was made diabetic with single-dose streptozotocin, and groups III and IV were rendered diabetic as group II and administered 10 and 20 mg RSV, respectively, intraperitoneally for 4 weeks. All animals were sacrificed after repeated DPOAE measurement. Apoptosis was investigated using caspase-3, Bax (Bcl-associated X protein), and TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) staining. Results: The DPOAE values in the diabetic group were found to be significantly lower compared with the other groups at 5,714 Hz and 8,000 Hz (P <.05). No significant difference in otoacoustic emission was detected in the comparison of the RSV doses (P >.05). The histopathologic investigation using caspase-3, Bax, and TUNEL staining showed that the mean rank of the diabetic group was significantly higher compared with the RSV10, RSV20, and control groups (DM > RSV10 > RSV20 > control) (P <.05). Conclusions: These results imply that RSV administration offered statistically significant protection for the cochleas of rats against diabetes. This protective effect improved histologically with higher doses. Level of Evidence: NA Laryngoscope, 129:E1–E6, 2019. © 2018 The American Laryngological, Rhinological and Otological Society, Inc.
dc.identifier.DOI-ID10.1002/lary.27253
dc.identifier.issn0023852X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14693
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc.
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCochlea
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDisease Models, Animal
dc.subjectDose-Response Relationship, Drug
dc.subjectImmunohistochemistry
dc.subjectIn Situ Nick-End Labeling
dc.subjectMale
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectResveratrol
dc.subjectcaspase 3
dc.subjectprotein Bax
dc.subjectresveratrol
dc.subjectresveratrol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectcochlea
dc.subjectcontrolled study
dc.subjectCorti organ
dc.subjectdistortion product otoacoustic emission
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectototoxicity
dc.subjectpriority journal
dc.subjectrat
dc.subjectsignal noise ratio
dc.subjectstreptozotocin-induced diabetes mellitus
dc.subjectTUNEL assay
dc.subjectanimal
dc.subjectapoptosis
dc.subjectcochlea
dc.subjectdisease model
dc.subjectdose response
dc.subjectdrug effect
dc.subjectexperimental diabetes mellitus
dc.subjectpathology
dc.subjectspontaneous otoacoustic emission
dc.subjectWistar rat
dc.titleThe effect of resveratrol on the histologic characteristics of the cochlea in diabetic rats
dc.typeArticle

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