Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy

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dc.contributor.authorBilgir, F
dc.contributor.authorBilgir, O
dc.contributor.authorCalan, M
dc.contributor.authorCalan, O
dc.contributor.authorIsikyakar, T
dc.date.accessioned2024-07-18T12:05:14Z
dc.date.available2024-07-18T12:05:14Z
dc.description.abstractObjective: Adhesion molecules are involved in inflammation, atherosclerosis and malignancy. This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO). Methods: Levels of soluble (s) intracellular adhesion molecule (ICAM)-1, s vascular cell adhesion molecule (sVCAM) VCAM-1 and sE-selectin were analysed in patients diagnosed with SHO, prior to administration of 50 mg/day levothyroxine orally for 3 months. Subsequently, levels of sICAM-1, sVCAM-1 and sE-selectin were reanalysed then compared with the pretreatment levels. Results: In 30 patients with SHO, levels of sICAM-1 were found to be significantly higher than those in healthy controls, (P = 0.001). Post-treatment sICAM-1 levels were significantly lower than pretreatment levels (P = 0.001). No significant differences were found in sVCAM-1 or sE-selectin levels between healthy controls and patients with SHO before treatment, or between patients with SHO pre- and post-treatment. Conclusions: Patients with SHO had significantly higher levels of sICAM-1 compared with controls. Levels became normal after treatment with levothyroxine. These findings emphasize the need for levothyroxine therapy in cases of SHO to normalize sICAM-1 levels. Such treatment helps to prevent the future development of atherosclerosis or cancer.
dc.identifier.issn0300-0605
dc.identifier.other1473-2300
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9626
dc.language.isoEnglish
dc.publisherSAGE PUBLICATIONS LTD
dc.subjectSE-SELECTIN LEVELS
dc.subjectTHYROID-DISORDERS
dc.subjectCANCER
dc.subjectREPLACEMENT
dc.subjectEXPRESSION
dc.subjectDYSFUNCTION
dc.subjectPREVALENCE
dc.subjectCOMMUNITY
dc.subjectICAM-1
dc.subjectWOMEN
dc.titleSubclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy
dc.typeArticle

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