Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats

Simple item page
dc.contributor.authorSahna, E
dc.contributor.authorTürk, G
dc.contributor.authorAtessahin, A
dc.contributor.authorYilmaz, S
dc.contributor.authorOlmez, E
dc.date.accessioned2024-07-18T12:01:17Z
dc.date.available2024-07-18T12:01:17Z
dc.description.abstractObjective: Myocardial ischemia and reperfusion (MI-R) leads to remote organ injury associated with oxidative stress. Melatonin is a well-known antioxidant and free-radical scavenger. This study was conducted to examine whether MI-R causes damage in the testes and sperm quality, and to investigate the possible protective effect of exogenous melatonin on these parameters in an in vivo rat model. Design: Experimental study. Setting: Experimental Research Center, Firat University Medical School, Elazig, Turkey. Patient(s): Eight-week-old male Wistar rats (n = 18). Intervention(s): To produce MI-R, a branch of descending left coronary artery was occluded for 30 minutes, followed by 120-minute reperfusion. Melatonin (10 mg/kg) or vehicle was given 10 minutes before ischemia via the jugular vein. Main Outcome Measure(s): Reproductive organ weights and epididymal sperm concentration, sperm motility, abnormal sperm rate, and testicular-tissue malondialdehyde (MDA) and glutathione (GSH) levels were examined after reperfusion. Result(s): MI-R significantly decreased epididymal sperm motility, and increased the tests-tissue level of MDA, compared to the control group. Administration of melatonin reversed the harmful effects of MI-R significantly. However, MI-R did not change sperm concentration, GSH levels, and reproductive organ weights. Conclusion(s): These findings indicate that MI-R leads to damage of testis and sperm motility, and melatonin protects againsts MI-R-induced reproductive-organ injury. These results may also encourage the use of antioxidants to reduce remove organ injury in the testis after MI-R.
dc.identifier.issn0015-0282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8316
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectASCORBIC-ACID
dc.subjectWISTAR RATS
dc.subjectDAMAGE
dc.subjectHEART
dc.subjectISCHEMIA/REPERFUSION
dc.subjectARRHYTHMIAS
dc.subjectINFERTILITY
dc.titleRemote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu