No pituitary gland volume change in medication-free depressed patients

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dc.contributor.authorEker, C
dc.contributor.authorOvali, GY
dc.contributor.authorOzan, E
dc.contributor.authorEker, OD
dc.contributor.authorKitis, O
dc.contributor.authorCoburn, K
dc.contributor.authorGonul, AS
dc.date.accessioned2024-07-18T12:05:44Z
dc.date.available2024-07-18T12:05:44Z
dc.description.abstractIncreased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N = 34) and age and sex matched healthy controls (N = 39). PGV did not differ between MDD patients and healthy controls [mean volume S.D.; 0.76 +/- 0.17 cm(3) and 0.75 +/- 0.14 cm(3); ANCOVA, F-1.69 = 1.25 p > 0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults. (c) 2008 Elsevier Inc. All rights reserved.
dc.identifier.issn0278-5846
dc.identifier.other1878-4216
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9965
dc.language.isoEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectDEXAMETHASONE-SUPPRESSION TEST
dc.subjectINVIVO ASSESSMENT
dc.subjectADRENAL AXIS
dc.subjectDISORDER
dc.subjectHORMONE
dc.subjectBIPOLAR
dc.subjectAGE
dc.subjectNEUROENDOCRINE
dc.subjectHYPERPLASIA
dc.subjectSECRETION
dc.titleNo pituitary gland volume change in medication-free depressed patients
dc.typeReview

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