Effect ofintra-abdominal boric acid in the experimental adhesion model

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dc.contributor.authorKabalar, RB
dc.contributor.authorSahin, ST
dc.contributor.authorAyhan, S
dc.date.accessioned2024-07-18T11:49:06Z
dc.date.available2024-07-18T11:49:06Z
dc.description.abstractBACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model. METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution.
dc.identifier.issn1306-696X
dc.identifier.other1307-7945
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3768
dc.language.isoEnglish
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERY
dc.subjectPREVENTION
dc.subjectBORON
dc.subjectSURGERY
dc.titleEffect ofintra-abdominal boric acid in the experimental adhesion model
dc.typeArticle

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