Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Rare Presentation of Anklylosing Spondylitis or a Paradoxical Reaction to Secukinumab?
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Date
2024
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Abstract
Purpose: To describe an atypical presentation of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in a patient with ankylosing spondylitis (AS) receiving secukinumab. Methods: Retrospective chart review. Results: A 48-year-old female patient with AS receiving secukinumab complained of impaired vision in her left eye. Left eye examination revealed multiple yellow-white lesions at the posterior pole and central subfoveal fluid.The lesions regressed without scarring. The case was diagnosed with clinically APMPPE. Conclusion: In AS patients, posterior uveitis can manifest as APMPPE. It should be recorded as an entity to be considered in the differential diagnosis. © 2023 Taylor & Francis Group, LLC.
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Acute Disease , Antibodies, Monoclonal, Humanized , Female , Fluorescein Angiography , Humans , Middle Aged , Pigment Epithelium of Eye , Retrospective Studies , Spondylitis , Spondylitis, Ankylosing , White Dot Syndromes , etanercept , HLA B27 antigen , infliximab , methotrexate , secukinumab , steroid , monoclonal antibody , secukinumab , acute posterior multifocal placoid pigment epitheliopathy , adult , ankylosing spondylitis , autofluorescence , best corrected visual acuity , blurred vision , case report , clinical article , differential diagnosis , drug withdrawal , eye , eye examination , female , fluorescence angiography , genetic screening , human , intraocular pressure , Letter , middle aged , multimodal imaging , optical coherence tomography , retrospective study , subretinal fluid , thorax radiography , uveitis , visual impairment , acute disease , ankylosing spondylitis , pathology , pigment epithelium , spondylitis , white dot syndrome