A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing

Simple item page
dc.contributor.authorKutlu, AK
dc.contributor.authorÇeçen, D
dc.contributor.authorGürgen, SG
dc.contributor.authorSayin, O
dc.contributor.authorÇetin, F
dc.date.accessioned2024-07-18T12:00:52Z
dc.date.available2024-07-18T12:00:52Z
dc.description.abstractThis study compared the effects of transcutaneous electrical nerve stimulation (TENS), saline solution (SS), povidone-iodine (PI), and lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing. Six experimental groups were established, each containing 8 rats: a healthy group with no incision wounds, an incision-control group, an incision and TENS group, an incision and SS group, an incision and PI group, and an incision and lavender oil group. Experiments continued for 5 days, after which the skin in the excision area was removed. Tissue concentrations of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-A were measured using enzyme-linked immunosorbent assay (ELISA). Tissue expressions of EGF, PDGF-A, and fibroblast growth factor (FGF)-2 were determined using immunohistochemistry. Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups. In particular, PDGF-A expressions in the dermis and EGF expression in the epidermis were significantly intense in the TENS group (p < 0.05). In addition, ELISA levels of growth factors such as PDGF-A and EGF were significantly higher in TENS group compared to the control group (p < 0.05). These immunohistochemical and ELISA results suggest that TENS may improve wound healing through increasing growth factors in the dermis and epidermis more than other topical applications.
dc.identifier.issn1741-427X
dc.identifier.other1741-4288
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8025
dc.language.isoEnglish
dc.publisherHINDAWI LTD
dc.subjectCYTOTOXICITY
dc.subjectRAT
dc.titleA Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu