The effects of lornoxicam on neuroprotection following diffuse traumatic brain injury in rats
| dc.contributor.author | Topcu I. | |
| dc.contributor.author | Vatansever S. | |
| dc.contributor.author | Bayram E. | |
| dc.contributor.author | Var A. | |
| dc.contributor.author | CetIn I. | |
| dc.contributor.author | Civi M. | |
| dc.date.accessioned | 2025-04-10T11:14:24Z | |
| dc.date.available | 2025-04-10T11:14:24Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Aim: In this study, the effects of lornoxicam on the prevention of secondary brain injury via the apoptotic pathway were studied in a rat model of head injury. Ma terIal and Methods: Thirty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by allowing a 450 g weight to fall two meters onto a metallic disk fixed to the intact skull. After head injury, the rats were randomly divided into two groups: Group I (n=15) rats were administered 2 mL saline intraperitoneally (controls); Group II (n=15) rats were administered 2 mL 1.3 mg kg-1 lornoxicam intraperitoneally. Brain tissue samples were divided into two pieces by interhemispheric incision for biochemical and histological analysis. Results: TUNEL positivity was seen in neuroglia cells of the brain cortex in both groups. While the immunoreactivities of caspase 8, 9 and Fas/ Fas ligand were similar in both groups, the immunoreactivity of caspase 3 was greater in Group I than Group II. MDA was significantly lower in Group II than in Group I (p<0.05). The decrease in SOD level was higher in Group I than Group II. ConclusIon: Lornoxicam did not prevent apoptosis in this rat model of brain trauma but causes a decrease. | |
| dc.identifier.DOI-ID | 10.5137/1019-5149.JTN.7749-13.0 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/50263 | |
| dc.publisher | Turkish Neurosurgical Society | |
| dc.title | The effects of lornoxicam on neuroprotection following diffuse traumatic brain injury in rats | |
| dc.type | Article |