The Role In Angiogenesis Of Galectin-3
Abstract
It is now thought that protein-carbohydrate interaction is ofgreat importance for the modulation of cell-cell andextracellular matrix (ECM)-cell interactions, which mediatevarious biological processes such as apoptosis, cancermetastasis, growth regulation and cell activation. Galectin-3expression is increased in neoplastic cell types. Galectin-3 isconnected with the process of development of tumors, includinggrowth, adhesion, proliferation and metastasis. It has a broadeffect on tumor development including cell proliferation,apoptosis, cell adhesion, invasion, angiogenesis andmetastasis. Consequently, it is of theut most importance tounderstand how Galectin-3 affects the angiogenic proteinVEGF and IL-6 cytokine and the pathogenesis of the diseases,and to correlate them with treatment, from the aspect ofdeveloping new treatment protocols and even eliminating riskfactors in healthy people before illness develops. This is a topicwhich is in need of research.