Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma: A Multicentric Study
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Date
2021
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Abstract
Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis. Copyright © 2020 American College of Occupational and Environmental Medicine.
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Keywords
Adenocarcinoma of Lung , Anaplastic Lymphoma Kinase , Asbestos , ErbB Receptors , Female , Humans , Lung Neoplasms , Mutation , Oncogenes , Protein-Tyrosine Kinases , Proto-Oncogene Proteins , anaplastic lymphoma kinase , asbestos , EGFR protein, human , epidermal growth factor receptor , oncoprotein , protein tyrosine kinase , ROS1 protein, human , clinical trial , female , genetics , human , lung adenocarcinoma , lung tumor , multicenter study , mutation , oncogene