Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma: A Multicentric Study

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dc.contributor.authorYilmaz S.
dc.contributor.authorDemirci N.Y.
dc.contributor.authorMetintas S.
dc.contributor.authorZamani A.
dc.contributor.authorKaradag M.
dc.contributor.authorGuçlu O.A.
dc.contributor.authorKabalak P.A.
dc.contributor.authorYilmaz U.
dc.contributor.authorAk G.
dc.contributor.authorKizilgoz D.
dc.contributor.authorOzturk A.
dc.contributor.authorYilmaz U.
dc.contributor.authorBatum O.
dc.contributor.authorKavas M.
dc.contributor.authorSerifoglu I.
dc.contributor.authorUnsal M.
dc.contributor.authorKomurcuoglu B.E.
dc.contributor.authorCengiz T.I.
dc.contributor.authorUlubay G.
dc.contributor.authorOzdemirel T.S.
dc.contributor.authorOzyurek B.A.
dc.contributor.authorKavurgacı S.
dc.contributor.authorAlizoroglu D.
dc.contributor.authorCelik P.
dc.contributor.authorErdogan Y.
dc.contributor.authorIn E.
dc.contributor.authorAksoy A.
dc.contributor.authorAltin S.
dc.contributor.authorGunluoglu G.
dc.contributor.authorMetintas M.
dc.date.accessioned2024-07-22T08:06:08Z
dc.date.available2024-07-22T08:06:08Z
dc.date.issued2021
dc.description.abstractObjective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis. Copyright © 2020 American College of Occupational and Environmental Medicine.
dc.identifier.DOI-ID10.1097/JOM.0000000000002115
dc.identifier.issn10762752
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13376
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectAdenocarcinoma of Lung
dc.subjectAnaplastic Lymphoma Kinase
dc.subjectAsbestos
dc.subjectErbB Receptors
dc.subjectFemale
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMutation
dc.subjectOncogenes
dc.subjectProtein-Tyrosine Kinases
dc.subjectProto-Oncogene Proteins
dc.subjectanaplastic lymphoma kinase
dc.subjectasbestos
dc.subjectEGFR protein, human
dc.subjectepidermal growth factor receptor
dc.subjectoncoprotein
dc.subjectprotein tyrosine kinase
dc.subjectROS1 protein, human
dc.subjectclinical trial
dc.subjectfemale
dc.subjectgenetics
dc.subjecthuman
dc.subjectlung adenocarcinoma
dc.subjectlung tumor
dc.subjectmulticenter study
dc.subjectmutation
dc.subjectoncogene
dc.titleEffect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma: A Multicentric Study
dc.typeArticle

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