Destiny of airway disease: interplay between epithelial barrier and the innate immune system
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Date
2022
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Abstract
When the organism encounters a foreign substance, it responds with mutual and regular interactions at different stages of the immune system. In airway diseases, the first encounter is at the epithelial level, where innate immune cells and their responses form the first leg of the protective mechanism. The most important barrier for environmental damage is the epithelial barrier. However, the epithelial barrier is not just a mechanical barrier. The formation of the microbiome on the epithelium and the tolerance or intolerance to environmental factors are vital. This vital balance is maintained between the epithelial surface and the subepithelial innate immune system. This is achieved by the epithelial line, which is a mechanical and functional barrier between them. In this respect, epithelial barrier function preservation has an important role in the development and prognosis of airway disease. © 2021 Taylor & Francis Group, LLC.
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Keywords
Epithelium , Immune System , actin , allergen , cadherin , epidermal growth factor receptor , immunoglobulin E , interleukin 1 , interleukin 6 , transforming growth factor beta , adaptive immunity , airway epithelium cell , airway remodeling , asthma , basolateral membrane , blood brain barrier , cell membrane , cell migration , cytokine production , enzyme stability , epithelial mesenchymal transition , epithelium , human , immune response , immune system , immunocompetent cell , immunopathology , innate immunity , prognosis , respiratory tract disease , Review , SARS coronavirus , epithelium