Destiny of airway disease: interplay between epithelial barrier and the innate immune system

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dc.contributor.authorYüksel H.
dc.contributor.authorTunca S.
dc.date.accessioned2024-07-22T08:05:07Z
dc.date.available2024-07-22T08:05:07Z
dc.date.issued2022
dc.description.abstractWhen the organism encounters a foreign substance, it responds with mutual and regular interactions at different stages of the immune system. In airway diseases, the first encounter is at the epithelial level, where innate immune cells and their responses form the first leg of the protective mechanism. The most important barrier for environmental damage is the epithelial barrier. However, the epithelial barrier is not just a mechanical barrier. The formation of the microbiome on the epithelium and the tolerance or intolerance to environmental factors are vital. This vital balance is maintained between the epithelial surface and the subepithelial innate immune system. This is achieved by the epithelial line, which is a mechanical and functional barrier between them. In this respect, epithelial barrier function preservation has an important role in the development and prognosis of airway disease. © 2021 Taylor & Francis Group, LLC.
dc.identifier.DOI-ID10.1080/21688370.2021.2020706
dc.identifier.issn21688362
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12984
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.rightsAll Open Access; Green Open Access
dc.subjectEpithelium
dc.subjectImmune System
dc.subjectactin
dc.subjectallergen
dc.subjectcadherin
dc.subjectepidermal growth factor receptor
dc.subjectimmunoglobulin E
dc.subjectinterleukin 1
dc.subjectinterleukin 6
dc.subjecttransforming growth factor beta
dc.subjectadaptive immunity
dc.subjectairway epithelium cell
dc.subjectairway remodeling
dc.subjectasthma
dc.subjectbasolateral membrane
dc.subjectblood brain barrier
dc.subjectcell membrane
dc.subjectcell migration
dc.subjectcytokine production
dc.subjectenzyme stability
dc.subjectepithelial mesenchymal transition
dc.subjectepithelium
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmune system
dc.subjectimmunocompetent cell
dc.subjectimmunopathology
dc.subjectinnate immunity
dc.subjectprognosis
dc.subjectrespiratory tract disease
dc.subjectReview
dc.subjectSARS coronavirus
dc.subjectepithelium
dc.titleDestiny of airway disease: interplay between epithelial barrier and the innate immune system
dc.typeReview

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