European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years

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dc.contributor.authorGaillard, EA
dc.contributor.authorKuehni, CE
dc.contributor.authorTurner, S
dc.contributor.authorGoutaki, M
dc.contributor.authorHolden, KA
dc.contributor.authorde Jong, CCM
dc.contributor.authorLex, C
dc.contributor.authorLo, DKH
dc.contributor.authorLucas, JS
dc.contributor.authorMidulla, F
dc.contributor.authorMozun, R
dc.contributor.authorPiacentini, G
dc.contributor.authorRigau, D
dc.contributor.authorRottier, B
dc.contributor.authorThomas, M
dc.contributor.authorTonia, T
dc.contributor.authorUsemann, J
dc.contributor.authorYilmaz, O
dc.contributor.authorZacharasiewicz, A
dc.contributor.authorMoeller, A
dc.date.accessioned2024-07-18T12:08:11Z
dc.date.available2024-07-18T12:08:11Z
dc.description.abstractBackground Diagnosing asthma in children represents an important clinical challenge. There is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-diagnosis of asthma is frequent in children. Methods A task force supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years using nine Population, Intervention, Comparator and Outcome (PICO) questions. The task force conducted systematic literature searches for all PICO questions and screened the outputs from these, including relevant full-text articles. All task force members approved the final decision for inclusion of research papers. The task force assessed the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Results The task force then developed a diagnostic algorithm based on the critical appraisal of the PICO questions, preferences expressed by lay members and test availability. Proposed cut-offs were determined based on the best available evidence. The task force formulated recommendations using the GRADE Evidence to Decision framework. Conclusion Based on the critical appraisal of the evidence and the Evidence to Decision framework, the task force recommends spirometry, bronchodilator reversibility testing and exhaled nitric oxide fraction as first-line diagnostic tests in children under investigation for asthma. The task force recommends against diagnosing asthma in children based on clinical history alone or following a single abnormal objective test. Finally, this guideline also proposes a set of research priorities to improve asthma diagnosis in children in the future.
dc.identifier.issn0903-1936
dc.identifier.other1399-3003
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10841
dc.language.isoEnglish
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.subjectEXHALED NITRIC-OXIDE
dc.subjectUK PRIMARY-CARE
dc.subjectLUNG-FUNCTION
dc.subjectBRONCHIAL HYPERRESPONSIVENESS
dc.subjectBRONCHODILATOR RESPONSE
dc.subjectCHILDHOOD ASTHMA
dc.subjectSPIROMETRY
dc.subjectACCURACY
dc.subjectFENO
dc.subjectTESTS
dc.titleEuropean Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years
dc.typeArticle

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